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KMID : 0355220110360040261
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Journal of Korean Academy Oral Medicine
2011 Volume.36 No. 4 p.261 ~ p.271
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A Comparison Study on Animal Models for Osteoarthritis in Temporomandibular Joint
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Yu Sun-Nyoung
Yi Young-Chul
Park Hae-Ryoun
Ryu Mi-Heon
Jeon Hye-Mi
Kim Kwang-Youn
Kim Sang-Hun
Ok Soo-Min
Ko Myung-Yun
Ahn Yong-Woo
Ahn Soon-Cheol
Jeong Su-Min
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Abstract
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Osteoarthritis in patients with temporomandibular disorders(TMDs) induces pain, limitation of mouth opening, occlusal problems, and most commonly affects their life quality. Control method and progressive process of osteoarthritis are being extensively researched. The researchers focus on histologic changes, synovial changes, muscular and ligamental changes and observed reaction to pain. Therefore most of them developed the animal model for osteoarthritis in TMD patients.
In this study, we applied several methods which induces osteoarthritis of temporomandibular joint(TMJ) in rats or mice. For locally induce osteoarthritis in TMJ, Monosodium iodoacetate(MIA) or interleukin-1α(IL-1α) were injected into TMJ joint space for 5 or 3 weeks. Other groups are chosen for osteoarthritis under systemic control including hormonal changes and aging.
To observe cellular change, increased collagen, degenerative bony destruction and distribution of proteoglycans (PGs), safranin-O staining and Masson’s trichrome staining were used.
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KEYWORD
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Animal model, Drug-induced arthritis, Osteoarthritis, Temporomandibular joint
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